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Over the Counter Pain Relievers

By Elizabeth Quinn, About.com

Updated: November 6, 2003

About.com Health's Disease and Condition content is reviewed by Medical Review Board

Part Two: NSAIDs vs. Acetaminophen

NSAIDs
NSAIDs prevent the body from manufacturing prostaglandins, substances that are produced naturally by the body. Prostaglandins have many functions, such as protecting the stomach lining, but some also cause pain and inflammation. NSAID’s work by blocking all prostaglandins. So while they block those that cause pain, they also block those that protect the stomach lining and can, therefore, cause stomach upset or gastrointestinal bleeding in some people. The risk increases with long-term use of NSAIDs. NSAIDs are effective at reducing aches, pain, fever, and inflammation.

Aspirin is classified as an NSAID, but it’s unique properties warrant special mention. Aspirin is an inexpensive, effective, nonaddicting pain reliever that reduces inflammation and fever. It has also been shown to help prevent heart attacks, and may well have other long-term benefits, including reducing colon cancer risk. It acts as a blood thinner and, therefore, can prevent blood clots.

Aspirin is not without it’s risks, though. It should not be taken by children under 16 who have chickenpox or flu symptoms, due to the risk of Reye’s syndrome. It is also not recommended for those with stomach problems, ulcers, kidney disease, bleeding disorders or aspirin allergies.

Acetaminophen
Acetaminophen (Tylenol and Panadol), is believed to act on the pain centers in the brain. They are the safest pain relievers because they don’t block prostaglandins, and therefore don’t cause any GI bleeding. Acetaminophen reduces pain and fever, however, it is not effective at reducing inflammation. It is ideal for treating osteoarthritis, or treating those with high blood pressure. High doses of acetaminophen may damage the liver, and rare reactions have been seen, such as rash and urinary problems.

What’s right for you?
It is always best to consult with your personal physician before you need to take a pain reliever. And if you take medications for any other medical condition (such as high blood pressure, arthritis, diabetes, ulcer or even acne), you should understand the possible interactions and side effect, so be sure to check with your physician or pharmacist before taking an OTC pain reliever.

In general, Ibuprofen (Advil, Motrin), Naproxen sodium (Aleve) or ketoprophen (Orudis KT) are the over-the-counter pain reliever of choice for anyone suffering from a sports injury that results in pain, swelling and inflammation. Buy generic, if possible. Generic brands work in the same manner and must meet the same standards as the brand-name equivalent, but will save you money. Always follow the label directions and don’t exceed the recommended does. Don’t take OTC drugs for more than 10 days, unless you’ve talked with your doctor or pharmacist first.

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